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Mercury poisoning is a type of metal poisoning due to exposure to mercury. Forms of mercury exposure include metal , vapor , salt , and organic compound. Prevention includes eating a diet low in mercury, removing mercury from medical and other devices, proper disposal of mercury, and not mining further mercury.

Common symptoms of mercury poisoning include peripheral neuropathy , presenting as paresthesia or itching , burning, pain , or even a sensation that resembles small insects crawling on or under the skin formication ; skin discoloration pink cheeks, fingertips and toes ; swelling; and desquamation shedding or peeling of skin. Mercury irreversibly inhibits selenium -dependent enzymes see below and may also inactivate S -adenosyl-methionine , which is necessary for catecholamine catabolism by catechol- O -methyl transferase.

Due to the body's inability to degrade catecholamines e. Affected children may show red cheeks , nose and lips, loss of hair , teeth , and nails , transient rashes, hypotonia muscle weakness , and increased sensitivity to light. Other symptoms may include kidney dysfunction e.

Fanconi syndrome or neuropsychiatric symptoms such as emotional lability , memory impairment, or insomnia. Thus, the clinical presentation may resemble pheochromocytoma or Kawasaki disease. Desquamation skin peeling can occur with severe mercury poisoning acquired by handling elemental mercury. The consumption of fish is by far the most significant source of ingestion-related mercury exposure in humans, although plants and livestock also contain mercury due to bioconcentration of mercury from seawater, freshwater, marine and lacustrine sediments, soils, and atmosphere, and due to biomagnification by ingesting other mercury-containing organisms.

All of these, except elemental liquid mercury produce toxicity or death with less than a gram. Consumption of whale and dolphin meat, as is the practice in Japan , is a source of high levels of mercury poisoning. Tetsuya Endo, a professor at the Health Sciences University of Hokkaido , has tested whale meat purchased in the whaling town of Taiji and found mercury levels more than 20 times the acceptable Japanese standard.

Human-generated sources, such as coal-burning power plants [14] emit about half of atmospheric mercury, with natural sources such as volcanoes responsible for the remainder. An estimated two-thirds of human-generated mercury comes from stationary combustion, mostly of coal.

Other important human-generated sources include gold production , nonferrous metal production, cement production, waste disposal , human crematoria , caustic soda production, pig iron and steel production, mercury production mostly for batteries , and biomass burning. Small independent gold-mining operation workers are at higher risk of mercury poisoning because of crude processing methods.

Such is the danger for the galamsey in Ghana and similar workers known as orpailleurs in neighboring francophone countries. While no official government estimates of the labor force have been made, observers believe 20,—50, work as galamseys in Ghana, a figure including many women, who work as porters. Similar problems have been reported amongst the gold miners of Indonesia. Some mercury compounds, especially organomercury compounds, can also be readily absorbed through direct skin contact.

Mercury and its compounds are commonly used in chemical laboratories, hospitals, dental clinics, and facilities involved in the production of items such as fluorescent light bulbs, batteries, and explosives. Many traditional medicines, including Ayurvedic medicine and Traditional Chinese medicine contain mercury and other heavy metals. No scientific data support the claim that mercury compounds in vaccine preservatives cause autism [20] or its symptoms.

Compounds of mercury tend to be much more toxic than either the elemental form or the salts. These compounds have been implicated in causing brain and liver damage. The most dangerous mercury compound, dimethylmercury , is so toxic that even a few microliters spilled on the skin, or even on a latex glove, can cause death. Methylmercury is the major source of organic mercury for all individuals.

Top predatory fish, such as tuna or swordfish , are usually of greater concern than smaller species. The period between exposure to methylmercury and the appearance of symptoms in adult poisoning cases is long. The longest recorded latent period is five months after a single exposure, in the Dartmouth case see History ; other latent periods in the range of weeks to months have also been reported.

No explanation for this long latent period is known. When the first symptom appears, typically paresthesia a tingling or numbness in the skin , it is followed rapidly by more severe effects, sometimes ending in coma and death. The toxic damage appears to be determined by the peak value of mercury, not the length of the exposure. Methylmercury exposure during rodent gestation, a developmental period that approximately models human neural development during the first two trimesters of gestation, [28] [29] has long-lasting behavioral consequences that appear in adulthood and, in some cases, may not appear until aging.

Prefrontal cortex or dopamine neurotransmission could be especially sensitive to even subtle gestational methylmercury exposure [30] and suggests that public health assessments of methylmercury based on intellectual performance may underestimate the impact of methylmercury in public health.

Ethylmercury is a breakdown product of the antibacteriological agent ethylmercurithiosalicylate, which has been used as a topical antiseptic and a vaccine preservative further discussed under Thiomersal below. Its characteristics have not been studied as extensively as those of methylmercury. It is cleared from the blood much more rapidly, with a half-life of seven to 10 days, and it is metabolized much more quickly than methylmercury.

It is presumed not to have methylmercury's ability to cross the blood—brain barrier via a transporter, but instead relies on simple diffusion to enter the brain. These compounds were used in indoor latex paints for their antimildew properties, but were removed in because of cases of toxicity. Mercury occurs as salts such as mercuric chloride HgCl 2 and mercurous chloride Hg 2 Cl 2 , the latter also known as calomel. Because they are more soluble in water, mercuric salts are usually more acutely toxic than mercurous salts.

Their higher solubility lets them be more readily absorbed from the gastrointestinal tract. Mercury salts affect primarily the gastrointestinal tract and the kidneys , and can cause severe kidney damage; however, as they cannot cross the blood—brain barrier easily, these salts inflict little neurological damage without continuous or heavy exposure. Quicksilver liquid metallic mercury is poorly absorbed by ingestion and skin contact.

Its vapor is the most hazardous form. Animal data indicate less than 0. Cases of systemic toxicity from accidental swallowing are rare, and attempted suicide via intravenous injection does not appear to result in systemic toxicity, [27] though it still causes damage by physically blocking blood vessels both at the site of injection and the lungs.

Though not studied quantitatively, the physical properties of liquid elemental mercury limit its absorption through intact skin and in light of its very low absorption rate from the gastrointestinal tract, skin absorption would not be high. Acute inhalation of high concentrations causes a wide variety of cognitive, personality, sensory, and motor disturbances. The most prominent symptoms include tremors initially affecting the hands and sometimes spreading to other parts of the body , emotional lability characterized by irritability, excessive shyness, confidence loss, and nervousness , insomnia , memory loss , neuromuscular changes weakness, muscle atrophy, muscle twitching , headaches, polyneuropathy paresthesia, stocking-glove sensory loss, hyperactive tendon reflexes, slowed sensory and motor nerve conduction velocities , and performance deficits in tests of cognitive function.

The toxicity of mercury sources can be expected to depend on its nature, i. High mercury exposures deplete the amount of cellular selenium available for the biosynthesis of thioredoxin reductase and other selenoenzymes that prevent and reverse oxidative damage, [41] which, if the depletion is severe and long lasting, results in brain cell dysfunctions that can ultimately cause death.

Mercury in its various forms is particularly harmful to fetuses as an environmental toxin in pregnancy , as well as to infants. Women who have been exposed to mercury in substantial excess of dietary selenium intakes during pregnancy are at risk of giving birth to children with serious birth defects. Mercury exposures in excess of dietary selenium intakes in young children can have severe neurological consequences, preventing nerve sheaths from forming properly.

Exposure to methylmercury causes increased levels of antibodies sent to myelin basic protein MBP , which is involved in the myelination of neurons, and glial fibrillary acidic protein GFAP , which is essential to many central nervous system CNS.

Diagnosis of elemental or inorganic mercury poisoning involves determining the history of exposure, physical findings, and an elevated body burden of mercury. If the exposure is chronic, urine levels can be obtained; hour collections are more reliable than spot collections. It is difficult or impossible to interpret urine samples of patients undergoing chelation therapy , as the therapy itself increases mercury levels in the samples.

Diagnosis of organic mercury poisoning differs in that whole-blood or hair analysis is more reliable than urinary mercury levels. Mercury poisoning can be prevented or minimized by eliminating or reducing exposure to mercury and mercury compounds. To that end, many governments and private groups have made efforts to heavily regulate the use of mercury, or to issue advisories about its use. For example, the export from the European Union of mercury and some mercury compounds has been prohibited since 15 March Mercury thermometers and mercury light bulbs are not as common as they used to be, and the amount of mercury they contain is unlikely to be a health concern if handled carefully.

However, broken items still require careful cleanup, as mercury can be hard to collect and it is easy to accidentally create a much larger exposure problem. Identifying and removing the source of the mercury is crucial. Decontamination requires removal of clothes, washing skin with soap and water, and flushing the eyes with saline solution as needed. However, several studies found no clear clinical benefit from DMSA treatment for poisoning due to mercury vapor.

Although it has been hypothesized that frequent low dosages of ALA may have potential as a mercury chelator, studies in rats have been contradictory. Chelation therapy can be hazardous if administered incorrectly. In August , an incorrect form of EDTA edetate disodium used for chelation therapy resulted in hypocalcemia , causing cardiac arrest that killed a five-year-old autistic boy. Experimental findings have demonstrated an interaction between selenium and methylmercury, but epidemiological studies have found little evidence that selenium helps to protect against the adverse effects of methylmercury.

Some of the toxic effects of mercury are partially or wholly reversible, either through specific therapy or through natural elimination of the metal after exposure has been discontinued.

Young's syndrome is believed to be a long-term consequence of early childhood mercury poisoning. Mercuric chloride may cause cancer as it has caused increases in several types of tumors in rats and mice, while methyl mercury has caused kidney tumors in male rats.

Mercury may be measured in blood or urine to confirm a diagnosis of poisoning in hospitalized people or to assist in the forensic investigation in a case of fatal overdosage.

Some analytical techniques are capable of distinguishing organic from inorganic forms of the metal. The concentrations in both fluids tend to reach high levels early after exposure to inorganic forms, while lower but very persistent levels are observed following exposure to elemental or organic mercury.

Chelation therapy can cause a transient elevation of urine mercury levels. Infantile acrodynia also known as "calomel disease", "erythredemic polyneuropathy", and "pink disease" is a type of mercury poisoning in children characterized by pain and pink discoloration of the hands and feet. Acrodynia resulted primarily from calomel in teething powders and decreased greatly after calomel was excluded from most teething powders in Acrodynia is difficult to diagnose, "it is most often postulated that the etiology of this syndrome is an idiosyncratic hypersensitivity reaction to mercury because of the lack of correlation with mercury levels, many of the symptoms resemble recognized mercury poisoning.

Mercury was once prescribed as a purgative. These include calomel mercurous chloride , and mercuric chloride. In , the Centers for Disease Control CDC and the American Academy of Pediatrics AAP asked vaccine makers to remove the organomercury compound thiomersal spelled "thimerosal" in the US from vaccines as quickly as possible, and thiomersal has been phased out of US and European vaccines, except for some preparations of influenza vaccine.

Since , the thiomersal in child vaccines has been alleged to contribute to autism, and thousands of parents in the United States have pursued legal compensation from a federal fund. Dental amalgam is a possible cause of low-level mercury poisoning due to its use in dental fillings. Discussion on the topic includes debates on whether amalgam should be used, with critics arguing that its toxic effects make it unsafe.

Some skin whitening products contain the toxic mercury II chloride as the active ingredient. When applied, the chemical readily absorbs through the skin into the bloodstream. However, cosmetics containing mercury are often illegally imported.

Following a certified case of mercury poisoning resulting from the use of an imported skin whitening product, the United States Food and Drug Administration warned against the use of such products.

Fluorescent lamps contain mercury, which is released when bulbs break. Mercury in bulbs is typically present as either elemental mercury liquid, vapor, or both, since the liquid evaporates at ambient temperature. Environmental Protection Agency recommends evacuating and airing out a room for at least 15 minutes after breaking a fluorescent light bulb.

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Diagnosis of elemental or inorganic mercury poisoning involves determining the history of exposure, physical findings, and an elevated body burden of mercury.

If the exposure is chronic, urine levels can be obtained; hour collections are more reliable than spot collections. It is difficult or impossible to interpret urine samples of patients undergoing chelation therapy , as the therapy itself increases mercury levels in the samples.

Diagnosis of organic mercury poisoning differs in that whole-blood or hair analysis is more reliable than urinary mercury levels. Mercury poisoning can be prevented or minimized by eliminating or reducing exposure to mercury and mercury compounds. To that end, many governments and private groups have made efforts to heavily regulate the use of mercury, or to issue advisories about its use.

For example, the export from the European Union of mercury and some mercury compounds has been prohibited since 15 March Mercury thermometers and mercury light bulbs are not as common as they used to be, and the amount of mercury they contain is unlikely to be a health concern if handled carefully.

However, broken items still require careful cleanup, as mercury can be hard to collect and it is easy to accidentally create a much larger exposure problem. Identifying and removing the source of the mercury is crucial.

Decontamination requires removal of clothes, washing skin with soap and water, and flushing the eyes with saline solution as needed. However, several studies found no clear clinical benefit from DMSA treatment for poisoning due to mercury vapor. Although it has been hypothesized that frequent low dosages of ALA may have potential as a mercury chelator, studies in rats have been contradictory. Chelation therapy can be hazardous if administered incorrectly.

In August , an incorrect form of EDTA edetate disodium used for chelation therapy resulted in hypocalcemia , causing cardiac arrest that killed a five-year-old autistic boy.

Experimental findings have demonstrated an interaction between selenium and methylmercury, but epidemiological studies have found little evidence that selenium helps to protect against the adverse effects of methylmercury.

Some of the toxic effects of mercury are partially or wholly reversible, either through specific therapy or through natural elimination of the metal after exposure has been discontinued. Young's syndrome is believed to be a long-term consequence of early childhood mercury poisoning. Mercuric chloride may cause cancer as it has caused increases in several types of tumors in rats and mice, while methyl mercury has caused kidney tumors in male rats.

Mercury may be measured in blood or urine to confirm a diagnosis of poisoning in hospitalized people or to assist in the forensic investigation in a case of fatal overdosage. Some analytical techniques are capable of distinguishing organic from inorganic forms of the metal. The concentrations in both fluids tend to reach high levels early after exposure to inorganic forms, while lower but very persistent levels are observed following exposure to elemental or organic mercury.

Chelation therapy can cause a transient elevation of urine mercury levels. Infantile acrodynia also known as "calomel disease", "erythredemic polyneuropathy", and "pink disease" is a type of mercury poisoning in children characterized by pain and pink discoloration of the hands and feet.

Acrodynia resulted primarily from calomel in teething powders and decreased greatly after calomel was excluded from most teething powders in Acrodynia is difficult to diagnose, "it is most often postulated that the etiology of this syndrome is an idiosyncratic hypersensitivity reaction to mercury because of the lack of correlation with mercury levels, many of the symptoms resemble recognized mercury poisoning.

Mercury was once prescribed as a purgative. These include calomel mercurous chloride , and mercuric chloride. In , the Centers for Disease Control CDC and the American Academy of Pediatrics AAP asked vaccine makers to remove the organomercury compound thiomersal spelled "thimerosal" in the US from vaccines as quickly as possible, and thiomersal has been phased out of US and European vaccines, except for some preparations of influenza vaccine.

Since , the thiomersal in child vaccines has been alleged to contribute to autism, and thousands of parents in the United States have pursued legal compensation from a federal fund. Dental amalgam is a possible cause of low-level mercury poisoning due to its use in dental fillings. Discussion on the topic includes debates on whether amalgam should be used, with critics arguing that its toxic effects make it unsafe.

Some skin whitening products contain the toxic mercury II chloride as the active ingredient. When applied, the chemical readily absorbs through the skin into the bloodstream. However, cosmetics containing mercury are often illegally imported.

Following a certified case of mercury poisoning resulting from the use of an imported skin whitening product, the United States Food and Drug Administration warned against the use of such products.

Fluorescent lamps contain mercury, which is released when bulbs break. Mercury in bulbs is typically present as either elemental mercury liquid, vapor, or both, since the liquid evaporates at ambient temperature.

Environmental Protection Agency recommends evacuating and airing out a room for at least 15 minutes after breaking a fluorescent light bulb. A report described a month-old toddler who suffered anorexia , weight loss, irritability, profuse sweating, and peeling and redness of fingers and toes. This case of acrodynia was traced to exposure of mercury from a carton of 8-foot fluorescent light bulbs that had broken in a potting shed adjacent to the main nursery.

The glass was cleaned up and discarded, but the child often used the area to play in. Mercury has been used at various times to assassinate people. In , Russian lawyer Karinna Moskalenko claimed to have been poisoned by mercury left in her car, [97] while in journalists Viktor Kalashnikov and Marina Kalashnikova accused Russia 's FSB of trying to poison them.

From Wikipedia, the free encyclopedia. Mercury poisoning Synonyms Mercury toxicity, mercury overdose, mercury intoxication, hydrargyria, mercurialism Elemental mercury Specialty Toxicology Symptoms Muscle weakness , poor coordination, numbness in the hands and feet [1] Complications Kidney problems , decreased intelligence [2] Causes Exposure to mercury [1] Diagnostic method Difficult [3] Prevention Decreasing use of mercury, low mercury diet [4] Medication Acute poisoning: This section needs additional citations for verification.

Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. September Learn how and when to remove this template message. Archived from the original on 19 November Retrieved 19 November Journal of Environmental and Public Health. Archived from the original on 20 November Journal of Medical Toxicology: United States Environmental Protection Agency. Archived PDF from the original on Agency for Toxic Substances and Disease Registry.

Archived from the original on Lay summary — Medscape Today Expert Opinion on Drug Safety. Chinese Herbal Drug Research Trends. Can J Neurol Sci. Archived at the Wayback Machine.

Journal of Human Hypertension. The Elements of Murder. Oxford University Press, Archived copy as title link accessed April 2, Toxicological Profile for Mercury. Archives of Environmental Health. British Journal of Industrial Medicine. Application of computer-administered neurobehavioral evaluation system". A molecular mechanism of mercury toxicity".

Journal of Biological Chemistry. Biosynthesis, recycling and degradation in mammals". May Archived at the Wayback Machine. Toxicology and Applied Pharmacology. The History of China Podcast. Event occurs at Archived from the original on 6 March Retrieved 24 January Crash Course World History. Archived from the original on 24 February Retrieved 24 February Retrieved August 27, Canadians in Early Hollywood , page Archived from the original on March 17, Andrews' diseases of the skin: You lost me with the rice though.

Could I use regular brown rice? You are most welcome. This recipe can work only with rice flour which can be bought at specialised oriental stire! I just noticed the dedication! Thank you so much Robert-Gilles! I will definitely be making this very soon.

This seems simple enough. You are most welcome! Whenever I upload a new article, I announce it on Foodbuzz! You are commenting using your WordPress. You are commenting using your Twitter account. You are commenting using your Facebook account. Notify me of new comments via email. Japanese dango are not complicated, although it might be better to make a lot at a time! If rice is no-wash type, skip 3 first steps. Let the rice dry for two hours. Finish the job with mortar and pestle.

Once the rice has been reduced completely topowder, work the pestle in for 5 more minutes. Add water and mix well with spoon. Divide into small portions and steam for 15 minutes. Previous Post Crustacean Species 5: Cheers, Robert-Gilles Like Like.

If rice is no-wash type, skip 3 first steps. Once the rice washing water is coming out clean, drain rice and spread ontowel. Take off all excess humidity. Let the rice dry for two hours. Pour rice in Blender/mixer. First work the blender for only a few seconds at a time until all the rice has been. Sushi is an almost flawless dish – the only real problem is that there never seems to be enough, right? This California Roll Casserole Will Make You Cancel Your Dinner Reservation. erinhurley August 11, Comments. Sushi is an almost flawless dish – the only real problem is that there never seems to be enough, right? Well this. The price of this item includes a contribution to a Product recycling fund to ensure that waste electrical and electronic equipment is collected and recycled in a responsible manner.